PR-619, ≥99%
| 【编号】：126704 【产品名称】：PR-619, ≥99% 【规格】：25MG 【用途】：   PR-619, ≥99%
Product Name： PR-619
CAS号：2645-32-1
分子量：223.28
介绍： PR-619
贮存： 储存温度-20°C
可溶性： 25°C： DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
生化和生理学机理：
Description：
IC50 Value： 3.93 μM (EC50, USP4); 7.2 μM (EC50, USP2 core); 5.10 μM (EC50, USP20) [1]
PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.
in vitro： PR-619 induces HCT116 cell death with EC50 values of 6.3 μM [1]. The general deubiquitylase (DUB) inhibitor, PR-619 attenuated KCa3.1 degradation, indicative of deubiquitylation being required for lysosomal delivery [2]. Proteasome inhibition by MG-132 and deubiquitinase inhibition by PR-619 induces significant changes to the ubiquitin landscape, but that not all ubiquitination sites regulated by MG-132 and PR-619 are likely substrates for the ubiquitin-proteasome system [3]. Cells were incubated with PR-619, a broad-range, reversible inhibitor of ubiquitin isopeptidases. Incubation with PR-619 led to morphological changes, the upregulation of heat shock proteins (HSP), including HSP70 and αB-crystallin, andwww.atcc360.com
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