PRX-08066
| 【编号】：127869 【产品名称】：PRX-08066 【规格】：5MG 【用途】：   PRX-08066
Product Name： PRX-08066
CAS号：866206-54-4
分子式：C19H17ClFN5S
分子量：401.89
贮存： 储存温度-20°C
可溶性： DMSO
生化和生理学机理：
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of pulmonary arteries. PRX-08066 significantly reduced peak PA pressure at 50 and 100 mg/kg (P < 0.05 and < 0.01, respectively) compared with MCT control animals. The 5-HT2BR antagonist PRX-08066 significantly attenuated the elevation in PA pressure and RV hypertrophy and maintained cardiac function. PRX-08066 prevents the severity of PAH in the MCT rat model.
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