Vc-MMAD, ≥99%
| 【编号】：125316 【产品名称】：Vc-MMAD, ≥99% 【规格】：5MG 【用途】：   Vc-MMAD, ≥99%
Product Name： Vc-MMAD
CAS号：1401963-17-4
分子式：C70H104N12O14S
分子量：1369.71
贮存： 储存温度-20°C
可溶性： 25°C： DMSO
生化和生理学机理：
Description：
Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent： WO 2013068874 A1).
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