白介素1受体拮抗剂(IL-1ra)(人类,rDNA衍生)
| 【编号】:NIBSC92/644 【产品名称】:白介素1受体拮抗剂(IL-1ra)(人类,rDNA衍生) 【规格】:支 【价格】:2600元 ![]() 白介素1受体拮抗剂(IL-1ra)(人类,rDNA衍生)
编号:NIBSC92/644
英文:Interleukin-1 Receptor Antagonist (IL-1ra) (Human, rDNA derived)
中文:白介素1受体拮抗剂
标准类型:非世卫组织参考材料
规格:1ml
描述:1. INTENDED USE
2. CAUTION
This preparation is not for administration to humans or animals in
the human food chain.
The preparation contains material of human origin, and either the final
product or the source materials, from which it is derived, have been
tested and found negative for HBsAg, anti-HIV and HCV RNA. As with
all materials of biological origin, this preparation should be regarded as
potentially hazardous to health. It should be used and discarded
according to your own laboratory's safety procedures. Such safety
procedures should include the wearing of protective gloves and
avoiding the generation of aerosols. Care should be exercised in
opening ampoules or vials, to avoid cuts.
3. UNITAGE
Each ampoule contains approximately 10.0 micrograms IL-1ra. The
assigned potency is 10 milli-units per ampoule.
4. CONTENTS
Country of origin of biological material: United Kingdom.
Each ampoule contains the residue after freeze drying of 1ml of a solution
that contained:
10.0 micrograms IL-1ra
3.0mg Trehalose
1.0 mg human serum albumin
5x10-2 mol/l sodium phosphate buffer
5. STORAGE
For economy of use, it is recommended that the solution be
sub-divided into several small aliquots and stored at -40oC or below.
Avoid repeated thawing/freezing.
Please note: because of the inherent stability of lyophilized material,
NIBSC may ship these materials at ambient temperature.
6. DIRECTIONS FOR OPENING
DIN ampoules have an 'easy-open' coloured stress point, where the
narrow ampoule stem joins the wider ampoule body. Various types of
ampoule breaker are available commercially. To open the ampoule,
tap the ampoule gently to collect material at the bottom (labelled) end
and follow manufactures instructions provided with the ampoule
breaker.
7. USE OF MATERIAL
No attempt should be made to weigh out any portion of the freeze-dried
material prior to reconstitution
Dissolve the total contents of the ampoule in a known volume of a suitable
solvent (distilled water, buffer or saline). Further dilutions should be made
in a medium containing carrier protein.
8. STABILITY
Reference materials are held at NIBSC within assured, temperaturecontrolled
storage facilities and they should be stored on receipt as
indicated on the label. An arbitrary unitage was assigned to this
preparation at the time of production without confirmation of long termstability. Evidence from similar materials prepared by an equivalent
process indicates that long term stability is likely to be maintained and the
material is suitably stable for shipment at ambient temperature without
any effect on the assigned values. Once reconstituted, diluted or
aliquoted, users should determine the stability of the material according
to their own method of preparation, storage and use. Users who have
data supporting any deterioration in the characteristics of any reference
preparation are encouraged to contact NIBSC.
9. REFERENCES
This standard was produced under WHO guidelines cited in the WHO
Technical Reports Series 1990 No.800 Annex 4.
10. ACKNOWLEDGEMENTS
The IL-1ra contained in this ampoule was selected from preparations
generously contributed by Synergen Inc. and The Upjohn Co. to NIBSC,
which is a WHO International Laboratory for Biological Standards.
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